Statin Intolerance

Statin Intolerance

Soghra Rabizadeh, MD.

Imam Khomeini Medical Complex,

Tehran University of Medical Sciences

Introduction

• Statin use has increased progressively in all age groups since 1988
• The American Heart Association/ American College of Cardiology guidelines have broadened the indications for their use.
• A 21% decrease in CVD mortality and morbidity(stroke and fatal coronary events) can be achieved by lowering LDL-C by 1.0 mmol/l (38.7 mg/dl)

Statin Use

• Dyslipidemia
• Coronary artery disease
• Acute coronary syndromes 
• Diabetes mellitus
• Stroke
• Hypertension
• CKD

Muscle symptoms

• Observational data show that about 10% to 20% of patients treated with statins complain of muscle symptoms (usually muscle aches)
• Analyses of muscle symptoms in double-blind, placebo-controlled randomized trials of statins have shown small numerical increases in muscle symptoms of about 0.3% (which is not statistically significant)